研究成果

1) Yoshimoto G, et al., *Akashi K. (11人中11番目): FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood 114, 5034-43, 2009

2) Kalaszczynska I,et al., Akashi K, *Sicinski P. (10人中9番目): Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 23: 352-65, 2009

3) Mori Y, et al., *Akashi K. (14人中14番目): Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. J Exp Med 206:183-93, 2009

4) Shimoda S, et al., Akashi K. (11人中11番目): CX3CL1: A signpost for biliary inflammation in primary biliary cirrhosis. Hepatology, 2009, in press.

5) Kohno K, et al. Akashi K (11人中11番目) : Infectious complications in patients receiving autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases. Transpl Infect Dis 11, 318-324, 2009.

6)Tabrizi SJ, et al, Akashi K (12人中12番目): T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins. J Immunol 182, 1490-9, 2009.

7) Kikushige Y, et al., Akashi K (9人中9番目). Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/monocyte progenitor stages to maintain cell survival. J Immunol 180, 7358-67, 2008.

8) Arinobu Y, et al.,*Akashi K. (11人中11番目): Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 1: 416-27, 2007

9) *Ishikawa F, et al., Akashi K, et al., Shultz LD. (20人中18番目): Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 25: 1315-21, 2007

10) Maeda T, et al., Akashi K, et al., *Pandolfi PP. (13人中10番目): Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 316: 860-6, 2007

11) Rosenbauer F, et al. Akashi K, et al., *Tenen DG. (16人中12番目): Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nat Genet 38: 27-37, 2006

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